PMI Bio applies state-of-the-art equipment and techniques to aid in early drug discovery and assay development for your protein target. Our toolbox contains a variety of methods for characterizing protein-large molecule and protein-small molecule interactions, enzymatic activity, and allosteric modulation, as well as for capturing disease-relevant activity in the test tube or whole cell. These assays can be utilized downstream during drug discovery, such as for primary HTP screening and lead development.

Target Characterization and Assay Development Tools

  • Structure-function analysis
  • Functional variant design
  • Targeted covalent modification
  • Stable cell line generation
  • Surface plasmon resonance (SPR)
  • Isothermal titration calorimetry (ITC)
  • Thermal shift assay (TSA)
  • Fluorescence-based methods (FRET, polarization, time resolved, etc.)

“Our goal is to pay attention to every detail and research every relevant aspect of your project to ensure the greatest possible accuracy and data integrity.”

Rockann Mosser

PhD in Biochemistry and Biophysics

  • 9 years’ industry experience including 4 years of assay development
  • Specialties: Biochemical, biophysical, living cell, and high-throughput assay development, enzyme kinetics, fluorescence, mammalian cell culture, monoclonal development of mammalian cell line overexpressing or knockdown of target protein, prokaryotic and eukaryotic recombinant protein expression and purification, and custom Tecan EVOware script development
  • Passions: Gardening, cooking, and DIY food preservation techniques